Research Overview

Nicotinamide adenine dinucleotide (NAD+) is a central redox cofactor cycling between NAD+ and NADH in dehydrogenase reactions. It supports mitochondrial respiration and cellular energy production and serves as a substrate for sirtuins and PARPs, making it a key tool compound in metabolism, aging and cellular-stress research.

Primary Research Areas

• Sirtuin/NAD+ metabolism & redox balance: models exploring NAD+ turnover, sirtuin activity and cellular NAD+/NADH ratios.
• Mitochondrial function & energy pathways: experiments on respiratory chain activity, ATP production and metabolic flux.
• Aging, DNA repair & cellular stress: studies involving PARP activity, genomic stability and stress-response signaling.
• Metabolic efficiency & recovery models: research on tissue energy status under high demand or post-stress conditions.